The workflow demonstrator has been conducted based on a pilot project at GSK where the B2A prototype has been deployed to end user scientists not already involved in the project. The demonstrator has been designed around verifying how a fully internal system of analytical tools and databases for gene sequence analysis, annotation and “Drugability” can easily be distributed across a number of organizations. The application is based on the Master Sequence Analysis Pipeline (MSAP) which is driven by the need to get high quality state of the art analysis for GSK genes of interest. The architecture of the demonstrator is based on the SIMDAT technology portfolio following a service-oriented architecture view of Grid computing.